Development of a Non-Enzymatic Electrochemical Glucose Sensor using Copper Oxide
Engineering
BME 281P
This project was conducted in order to develop a simple, non-enzymatic method of glucose detection. Glucose serves as a primary source of energy for almost all organisms. Diabetes, a disease characterized by chronic elevated levels of glucose, affects millions of people worldwide, and particularly in low-income countries. This increases the pressure to develop a stable, reproducible, time, and cost-effective glucose biosensor. Traditional biosensors use glucose oxidase to catalyze the oxidation of glucose in electrochemical sensors, but enzymes have been found to be less stable and more expensive than alternative methods. Copper oxide has been explored as a potential alternative to traditional enzymatic sensors due to its highly catalytic properties. In this paper, copper oxide was deposited onto a platinum electrode and was used to detect glucose under alkaline conditions. Glucose was detected in the range of 0.625μM to 30mM, and the sensor showed no response against other sugars or potentially interfering species.
