Metal Detection with Functionalized Nanopores
Engineering
BME 195
Solid-state nanopores are ideal candidates for the development of portable and inexpensive analytical devices. Furthermore, their high chemical stability and ease of functionalization allows the targeting of a wide range of analytes. Here we discuss the applications of glass conical nanopores functionalized with multiple layers of polyelectrolytes for the detection of copper ions. Applied voltage across the nanopore induces ion flow that is translated into real time electrical signals. Both functionalization of polyelectrolytes and detection of copper cations can be monitored in real time through the disturbance in ion flow. We can also reverse the interactions of copper cations with the polyelectrolytes by switching the pH environment of the nanopore and thereby regenerating the nanopore. The functionalized nanopore can be applied in the study of thermodynamic and kinetic properties of the analyte-receptor interaction. With further improvement in its detection sensitivity, functionalized nanopores can be a quick, inexpensive tool used to screen for metal ions in polluted waters.
